abnormality
acute disease
adverse circumstances
adversity
affection
aggravation
ailment
allergic disease
allergy
anguish
annoyance
atrophy
bacterial disease
bane
birth defect
bitter cup
bitter draft
bitter draught
bitter pill
blight
bugbear
bummer
burden
burden of care
calamity
calvary
cankerworm of care
cardiovascular disease
care
catastrophe
chronic disease
circulatory disease
complaint
complication
condition
congenital defect
cross
crown of thorns
crucible
crushing burden
curse
death
defect
deficiency disease
deformity
degenerative disease
destruction
difficulties
disgrace
distress
embarrassment
hardship
humiliation
loneliness
malady
perplexity
regret
sickness
suffer
temptation
woe
addiction
benediction
constriction
contradiction
conviction
crucifixion
depiction
dereliction
diction
eviction
fiction
friction
infliction
interdiction
jurisdiction
nonfiction
prediction
restriction