aching heart
affliction
agonizingness
agony
anguish
bale
bleeding heart
broken heart
brokenheartedness
care
desolateness
desolation
dole
excruciatingness
excruciation
grief
heartache
heartbrokenness
heartsickness
heartsoreness
regret
rue
sorrow
torment
tormentingness
torture
torturousness
woe
dolor
dolour
awfulness
bereavement
betrayal
bleakness
chagrin
cheerlessness
despondency
discouragement
disillusionment
forlornness
frustrations
home-sickness
homesickness
hopelessness
humiliation
loathe
loneliness
self-hatred
self-pity
unhappiness
wretchedness