permanent
beyond recall
beyond remedy
changeless
chronic
confirmed
constant
cureless
deep-dyed
deep-fixed
deep-rooted
deep-seated
deep-set
deep-settled
direct
dyed-in-the-wool
established
fast
final
fixed
gone
immediate
immedicable
immutable
implanted
incommutable
inconvertible
incorrigible
inculcated
incurable
indefeasible
inert
infixed
ingrained
inoperable
instilled
insusceptible of change
intransmutable
invariable
inveterate
irreclaimable
irrecoverable
irredeemable
irreformable
irremediable
irreparable
irrepealable
irretrievable
irrevocable
lasting
adverse
age-related
behavioral
catastrophic
debilitate
degenerative
disastrous
ecological
imminent
inexorable
long-term
metabolic
neurological
pharmacological
reuptake
reversible
selective