disagreeable
stimulative
uncomfortable
acerbic
acid
acrid
aggravating
aggravative
angering
annoying
asperous
astringent
biting
bitter
bothering
bothersome
caustic
chafing
contentious
cutting
disturbing
escharotic
exasperating
exasperative
excitatory
exciting
fretting
galling
grating
grinding
harassing
harsh
importunate
importune
inflammatory
irking
irksome
irritant
irritative
keen
mordant
nettlesome
nettling
nose-tickling
penetrating
pesky
calmative