ill-natured
acerb
acerbate
acerbic
acid
acidic
acidulent
acidulous
acrimonious
adrenal
bearish
bitchy
bitter
blase
burning
cankered
cantankerous
caustic
choleric
churlish
crabbed
cranky
cross
cross-grained
crusty
cussed
disagreeable
dispirited
eccrine
embittered
endocrine
excitable
exocrine
fed-up
feisty
fractious
fretful
glandular
glandulous
gloomy
gonadal
good and tired
holocrine
huffish
huffy
humoral
irascible
irked
irritable
jaded
life-weary
captious
censorious
crossgrained
froward
ill-humoured
melancholic
misanthropic
miserly
morose
quarrelsome
quick-tempered
snappish
spleeny
testy
unamiable
unkind