acute
afflictive
aggravating
agonizing
annoying
atrocious
biting
bothering
bothersome
chafing
consuming
cramping
cruel
desolating
disquieting
distressful
distressing
disturbing
exasperating
excruciating
fretting
galling
gnawing
grave
griping
harassing
hard
harrowing
harsh
heartbreaking
heartrending
heartsickening
heartwounding
hurtful
hurting
importunate
importune
irking
irksome
irritating
painful
paroxysmal
pesky
pestering
pestiferous
pestilent
pestilential
piercing
plaguesome
plaguey